Protein Details: Potassium voltage-gated channel subfamily V member 2

Protein ID

ICDB_Pro_1318

Protein Name

Potassium voltage-gated channel subfamily V member 2

Gene Name

KCNV2

Organism

Homo sapiens (Human)

Length

545 amino acids

AlphaFoldDB

AF-Q8TDN2-F1-model_v4.pdb

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values

Sequence

MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLTPRQEN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Retinal Cone Dystrophy 3B and Cone Dystrophy With Supernormal Rod Response

Location

Detected in lung; liver; kidney; pancreas; spleen; thymus; prostate; testis; ovary and colon.

DOI ID

10.1073/pnas.122617999; 10.1038/nature02465; 10.1101/gr.2596504; 10.1086/507568; 10.1002/mgg3.1795

RefSeq

NP_598004.1